Prediction of Immune Response: Utilizing ML Models Based on RCD Status

Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to autonomous and orderly death of cells controlled by genes in order to maintain the stability of the internal environment. It plays a key role in immune response.  Immune checkpoint inhibitors (ICIs) are a type of immunotherapy drug that treat cancer by blocking proteins that prevent the immune system from attacking cancer cells. A team of researchers from Xiangya Hospital, Central South University, China, created machine learning models that can predict the ICI response and survival rate based on RCD status for various cancer types. Research details are in https://www.nature.com/articles/s41698-024-00570-5